By A. Alonso, M.G. Hennerici, S. Meairs, J. Bogousslavsky
Diagnostic ultrasound has develop into an basic device for comparing cerebrovascular ailments and performs a sought after function in regimen scientific perform. Many courses try and disguise the continual growth of its diagnostic or even healing functions. even if, the impression ultrasound has made in recent times within the fields of animal experiences and human examine is much less renowned. This ebook presents an outline on interesting present makes an attempt in neurological illnesses, starting from experimental techniques to verified imaging modes able to be included into the regimen of day-by-day perform. the 1st a part of the publication concentrates on simple ideas of neurosonology and makes a speciality of distinction imaging, particular ultrasound distinction brokers and defense points. the next chapters care for diverse vascular ultrasound functions, permitting an optimized characterization of atherosclerotic affliction and tracking of cerebral autoregulation. moreover, the function of parenchymal ultrasound imaging in cerebrovascular illnesses and stream problems is illustrated. the ultimate chapters examine promising new healing techniques enforcing ultrasound even though they're nonetheless not more than experimental. The e-book might be hugely suggested to scientific neurologists with sturdy wisdom in scientific ultrasound who desire to achieve a compact and up-to-date perception into the plethora of features of neurosonology sooner or later.
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Extra resources for Translational Neurosonology
1159/000366234) tion in selected trials but that findings have been inconsistent at times, suggesting caution in using CIMT as a surrogate end point . However, both studies should be interpreted with caution because they both may suffer from considerable flaws as reviewed in detail elsewhere . Besides ecological fallacy, flaws may include heterogeneity in treatment efficacy, patient populations and the methodology of measuring CIMT in addition to a lack of power . An individual participant data analysis is needed to overcome the flaws of these earlier meta-analyses using aggregated data.
2 Porter TR, Xie F, Kricsfeld A: The mechanism and clinical implication of improved left ventricular videointensity following intravenous injection of multifold dilutions of albumin with dextrose. Int J Card Imaging 1995;11:117–125. 3 Lindner JR, Wei K, Kaul S: Imaging of myocardial perfusion with sonovue (TM) in patients with a prior myocardial infarction. Echocardiography 1999; 16: 753–760. 4 McDonald DM, Choyke PL: Imaging of angiogenesis: from microscope to clinic. Nat Med 2003;9:713– 725. 5 Meairs S: Contrast-enhanced ultrasound perfusion imaging in acute stroke patients.
5 , this finding has since been replicated in rats. The effect was greatest when ultrasound exposures were triggered at end systole in both humans and rodents. A comparison of the induction of PVCs by the three agents – Definity, Albunex, and Optison – in rodent studies found a similar threshold for all agents, but exposures in the presence of Definity resulted in the lowest number of events . A second human study was unable to induce PVCs at MI values ≤1 . 4) . This rupture, as well as the induction of petechiae, has been reported by other investigators in a number of biological models.
Translational Neurosonology by A. Alonso, M.G. Hennerici, S. Meairs, J. Bogousslavsky