Download e-book for kindle: Histophilus somni: Biology, Molecular Basis of Pathogenesis, by Thomas J. Inzana

By Thomas J. Inzana

ISBN-10: 3319295543

ISBN-13: 9783319295541

ISBN-10: 331929556X

ISBN-13: 9783319295565

This quantity reports the present knowing of the taxonomy, disorder syndromes, genetics, biology, and pathogenic components of Histophilus somni, in addition to the host immune reaction to this pathogen. H. somni is without doubt one of the most vital bacterial pathogens in farm animals and different ruminants, and its virulence components are hugely conserved with Haemophilus influenzae and different individuals of the Pasteurellaceae. H. somni has been famous as an incredible reason behind thrombotic meningoencephalitis, respiration disorder syndromes, myocarditis, reproductive affliction syndromes, polyarthritis, mastitis, ocular illness, and septicemia. the one identified habitats of H. somni are the mucosal surfaces of ruminants, making this bacterium an opportunistic pathogen. even though it is able to inflicting irritation at systemic websites and is poisonous to epithelial and phagocytic cells, the bacterium’s large choice of virulence components act basically as a safeguard opposed to, or to flee popularity from, host innate and adaptive immunity.

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Extra info for Histophilus somni: Biology, Molecular Basis of Pathogenesis, and Host Immunity

Example text

IHC increases the overall rate of positive diagnosis of pulmonary and cardiac histophilosis, particularly in tissues from antibiotic-treated animals (Tegtmeier et al. 1995; Bryson et al. 1990). Given the pitfalls of attempting to grow a fastidious bacterium like H. somni from tissue or swabs from tissues with varying degrees of autolysis, sometimes in the presence of other pathogens, and following antibiotic treatment, one approach to diagnosis is a combination of IHC and PCR when H. somni is suspected.

A tentative identification of H. somni is based on the growth of small tan/yellow-white colonies on blood agar plates incubated in 10 % CO2, with no or very little growth in air. A final identification is based on Gram staining (pleomorphic Gram-negative bacilli or coccobacilli, 1 μm × 1–3 μm in size), oxidase-positive, catalase-negative, and variable indole production, fermentation of glucose, and nitrate reduction (Markey et al. 2013). H. somni is often isolated from lungs along with other bacterial pathogens such as P.

As in cattle, CNS disease may occur as TME, or as suppurative leptomeningitis-ventriculitis-choroiditis (Philbey et al. 1991). The means of transmission is unknown. Septicemia can be induced experimentally by intranasal and intravenous inoculation (Rahaley 1978a, b). Suppurative leptomeningitisventriculitis without vasculitis can be induced by intracisternal inoculation of both septicemic and one of two preputial strains tested (Lees et al. 1994). As with cattle, stress and crowding are presumed to be precipitating factors.

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Histophilus somni: Biology, Molecular Basis of Pathogenesis, and Host Immunity by Thomas J. Inzana

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