Antineoplastic Agents - download pdf or read online

By Stanley T. Crooke and Archie W. Prestayko (Eds.)

ISBN-10: 0121978036

ISBN-13: 9780121978037

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Wiernik, P. , Ziegler, J. , and DeVita, V. T. (1974). Cancer 34, 993-1000. Schein, P. , Woolley, P. , and Anderson, T. (1976). Cancer Treat. Rep. 60, 801-805. Schein, P. , Bull, J. , and Hoth, D. (1978). Cancer Res. 38, 257-260. , Cheng, C. , and Weinstein, I. B. (1973). Cancer Res. 33, 1921-1924. Skipper, H. , Schabel, F. , Trader, M. , Thomson, J. R. (1961). Cancer Res. 21, 1154-1164. Smulson, M. , Schein, P. , Mullins, G. , and Sudhakar, S. (1977). Cancer Res. 37, 3006-3012. Walker, M. , and Gehan, E.

W. (1977). Cancer Res. 37, 1450-1454. Kovach, J. , Moertel, C. , Schutt, A. , Hahn, R. , and Reitemeier, R. J. (1974). Cancer (Philadelphia) 33, 563-567. Ludlum, D. , Kramer, B. , and Fenselau, C. (1975). Biochemistry 14, 5480-5485. Moertel, C. , Schutt, A. , Hahn, R. , and Reitemeier, R. J. (1975). J. Nati. Cancer lnst. 54, 69-71. Montgomery, J. , McCaleb, G. , Kirk, M. C , and Johnston, T. P. (1975). J. Med. Chem. 18, 568-571. Panasci, L. C , Fox, P. , and Schein, P. S. (1977a). Cancer Res. 37, 3321-3328.

L. (1971). Mol. Pharmacol. 7, 519-529. Struck, R. , Kirk, M. C , Witt, M. , and Laster, W. , Jr. (1975). Biomed. Mass Spectrom. 2, 46. , and Yamaguchi, K. (1973). J. Am. Chem. Soc. 95, 985-986. 3 NITROSOUREAS Philip S. Schein I. II. III. IV. V. VI. Introduction Decomposition and Metabolism Mechanism of Action A. Alkylation B. Carbamolylation Clinical Use Clinical Toxicities Discussion References 37 38 39 39 40 41 44 46 47 I. INTRODUCTION In 1959, 1-methyl-l-nitro-3-nitrosoguanidine (MNNG) was reported to have limited but reproducible antitumor activity aginst the murine LI210 leukemia.

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Antineoplastic Agents by Stanley T. Crooke and Archie W. Prestayko (Eds.)

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